Science, Bindi 323,Útgáfur 5917-5922American Association for the Advancement of Science, 2009 |
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Síða 1022
... SIRT1 overexpression enhances the ability of cul- tured cells to survive prolonged exposure to lethal heat shock temperatures . SIRT1 there- fore functions as a positive cofactor of HSF1 and enhances the heat shock response . Aging and ...
... SIRT1 overexpression enhances the ability of cul- tured cells to survive prolonged exposure to lethal heat shock temperatures . SIRT1 there- fore functions as a positive cofactor of HSF1 and enhances the heat shock response . Aging and ...
Síða 1064
... sirt1 hsp70 18S + + + SIRT1 siRNA 0 0.5 1 2 4 6 HSF1 binding ( fold ) C 30 25 20 15 10 5 0 HS ( h ) from all major classes of heat shock genes ( hsp70 , hsp90 , hsp40 , and hsp27 ) ( Fig . 1A ) , which in- dicated that the sirtuins are ...
... sirt1 hsp70 18S + + + SIRT1 siRNA 0 0.5 1 2 4 6 HSF1 binding ( fold ) C 30 25 20 15 10 5 0 HS ( h ) from all major classes of heat shock genes ( hsp70 , hsp90 , hsp40 , and hsp27 ) ( Fig . 1A ) , which in- dicated that the sirtuins are ...
Síða 1065
therefore investigated SIRT1 as a candidate for regulation of the HSR . When SIRT1 was de- □ pleted by small interfering RNA ( siRNA ) , the amount of hsp70 mRNA produced during a 6- hour heat shock was one - fourth of that in cells ...
therefore investigated SIRT1 as a candidate for regulation of the HSR . When SIRT1 was de- □ pleted by small interfering RNA ( siRNA ) , the amount of hsp70 mRNA produced during a 6- hour heat shock was one - fourth of that in cells ...
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acid activity AMPARs analysis aphid applications astrocytes binding Biol Biology Bmp4 Cancer caspase catalysts Cell Biology cell death Center Chemistry David Department disease disgust domain dsRNA dynamics E-mail effect electron energy Engineering enzyme experiments expression factor Fermi surface function Gadd45b gene genetic genome Grem1 heat shock HSF1 imaging increase indicated Institute interactions kinetochore lattice layer leaf Lett levels magnetic membrane meropenem mice molecular mRNA mutations neurons Neurosci NH Chair observed ocean ORE1 oxide pathway phenotype Phys plants Pol IV position postdoctoral potential protein proteomics ratio receptors References and Notes region regulation response RIG-I sample says Science scientists senescence sequence signaling siRNA SIRT1 species structure substrate Supporting Online Material surface SWNTs table S1 target Technology temperature tion transcription Univ University Vice Chair Waterville Valley Resort zircon