Mass Spectrometry in Drug DiscoveryDavid T. Rossi, Michael Sinz CRC Press, 7. nóv. 2001 - 432 síður Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It provides time- and cost-efficient approaches for the generation and analysis of effective pharmaceuticals, covers advances in combinatorial chemistry, molecular biology, bioanalysis automation, and computing, and demonstrates the use of mass spectrometry in the assessment of disease states, drug targets, and potential drug agents. |
Efni
INTRODUCTION | 1 |
The Impact of Atmospheric Pressure Ionization David T Rossi | 15 |
INSTRUMENTATION | 25 |
EXPERIMENTAL STRATEGIES | 85 |
The LCMS Experiment Lucinda RH Cohen and David T Rossi | 125 |
Sample Preparation and Handling for LCMS in Drug Discovery David T Rossi | 171 |
APPLICATIONS | 215 |
Drug Hydrophobicity and Transport Barbra H Stewart Steven M Michael and Narayanan Surendran | 245 |
The Mass Spectrometer in Drug Metabolism Michael W Sinz and Terry Podoll | 271 |
Mass SpectrometryAssisted Applications of StableLabeled Compounds in Pharmacokinetic and Drug Metabolism Studies Krishna Ramalingam Iyer | 337 |
Cassette Dosing in Drug Discovery Jayesh Vora David T Rossi and Erick K Kindt | 357 |
Applications of MicrodialysisMass Spectrometry to Drug Discovery David J Weiss Ryan M Krisko and Craig E Lunte | 377 |
Future Directions for Mass Spectrometry in Drug Discovery David T Rossi and Richard AJ OHair | 399 |
| 415 | |
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Common terms and phrases
acetonitrile amines amino acids Anal Chem analysis analyte APCI applications approach assay automated buffer capillary cassette dosing cell charged chemical ionization chromatographic column combinatorial chemistry combinatorial libraries components compounds concentration conjugation detection detector determination drug discovery drug metabolism electron electrospray ionization elution enzymes example Figure formation fragmentation gas phase gas-phase glucuronide HPLC injection instrument intestinal ion source ion suppression isotope effects kinetic LC/MS limited liver mass analyzer matrix membrane Metab metabolites method microdialysis mobile phase molecular weight molecules MS/MS NCES neutral NH₂ NMEs oxidation peak peptides perfusion permeability Pharm pharmaceutical pharmacokinetic plasma potential probe product ion protein proton quadrupole ion trap quadrupole mass quadrupole mass analyzer quantitation reactions sample preparation scanning screening selectivity sensitivity separation solid-phase extraction solvent spectra stable isotopes stable-labeled structure studies synthesis tandem mass spectrometry techniques throughput tion transport typically vitro vivo voltage workstations
Tilvísanir í bókina
Using Mass Spectrometry for Drug Metabolism Studies Walter A. Korfmacher Engin sýnishorn í boði - 2004 |
Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery Klaus Wanner,Georg Höfner Takmarkað sýnishorn - 2007 |