societies composing the Federation, in addition to two sessions conducted independently. The following communications were presented at the independent sessions.

Scientific program. FIRST SESSION. MONDAY, DEC. 28, 2.00 p. m. Graham Lusk: Presidential address, The influence of food on metabolism.-S. R. Benedict and E. Osterberg: The retention of parenterally introduced creatin under various nutritive conditions in the dog. -Otto Folin and W. Denis: The occurrence of creatin in urine.-F. D. Zeman and P. E. Howe: The excretion of creatin during fasting.-J. L. Morris: The determination of creatin and creatinin in urine; and the occurrence of creatin.-W. C. Rose: The influence of protein feeding on the elimination of creatin in starvation.-P. A. Kober: The nephelometric estimation of purin bases, including uric acid, in blood and urine.-W. H. Welker and Grover Tracy: The use of aluminium hydroxid in connection with nitrogen partition in urinary analysis.-H. R. Fishbach and P. B. Hawk: The fecal bacteria output as influenced by dietary alterations. N. Hendrickson, E. L. Connolly, B. M. Hendricks and M. E. Pennington: The dextrose content of the egg of the common fowl.-H. J. Corper: A method for determining and comparing the local toxicity of chemical compounds.-E. A. Graham: The mechanism of the toxicity of halogen narcotics.

SECOND SESSION. TUESDAY, DEC. 29, 9.00 a. m. Olaf Bergeim: Some influences affecting the action of phospho-nuclease.H. H. Bunzel: Biological oxidizability and chemical constitution (II).—Н. І. Mattill and H. A. Mattill: Digestive processes in Limulus.-R. E. Swain: The action of alkaline hydrolytic agents on allantoin.-Arno Viehoever, C. O. Johns and C. L. Alsberg: Cyanogenesis in plants: (I) Studies on Sieglingia sesleroides.-R. T. Woodyatt: Experiments with d-l-glyceric aldehyde.-J. J. R. Macleod and R. G. Pearce: The level of sugar in the blood flowing from the liver under laboratory conditions.-F. S. Lee and E. L. Scott: The action of certain atmospheric conditions on muscular work and blood-sugar.-P. A. Shaffer and R. S. Hubbard: The level of bloodsugar in the dog. -C. C. Fowler and P. B. Hawk: Sulfur partition as influenced by water drinking.-E. C. Kendall: A method for the decomposition of the proteins of the thyroid with a description of certain constituents.-F. D. Zeman, Jerome Kohn and P. E. Howe: Variations in factors associated with acidity of human urine during a seven-day fast and during subsequent non-protein and normal feeding periods.

PAPERS READ BY TITLE. Jacob Rosenbloom: The effect of intravenous injections of radium on the urinary nitrogen and sulfur partition. Jacob Rosenbloom: The effect of external application of radium on the metabolism of a cancer patient.-P. H. Mitchell: Carbohydrate metabolism in the oyster.-Amos W. Peters: Studies on the pathology of the feeble-minded: (I) The glycosuric reaction and its relation to their pathology.-G. W. Raiziss and H. Dubin: A method for the determination of benzoic acid in urine.-G. W. Raiziss and H. Dubin: The synthesis of hippuric acid in the animal body.

Executive proceedings. NEW MEMBERS: Olaf Bergeim, Jefferson Med. Coll.; Alex. T. Cameron, Univ. Manitoba; G. H. A. Clowes, Gratwick Lab., Buffalo, N. Y.; B. M. Duggar, Missouri Botan. Garden; Cyrus H. Fiske, Harvard Med. Sch.; R. A. Hall, Univ. Minn.; C. G. Imrie, Univ. Toronto; Benjamin Kramer, State Univ. Iowa; A. Bruce Macallum, Jr., Univ. Toronto; J. F. McClendon, Univ. Minn.; J. Lucien Morris, Washington Univ. Med. Sch.; Max Morse, Univ. Wis.; V. H. Mottram, McGill Univ.; C. F. Nelson, Univ. Kansas; E. L. Ross, Northwestern Univ. Med. Sch.; E. C. Shorey, U. S. Dep't of Agric.

OFFICERS-ELECT: President-Walter Jones; Vice-presidentCarl L. Alsberg; Secretary-P. A. Shaffer; Treasurer-D. D. Van Slyke; Additional members of the Council-Otto Folin, Graham Lusk, L. B. Mendel; Nominating Commit.-J. J. Abel, S. R. Benedict, H. D. Dakin, P. B. Hawk, J. J. R. Macleod, E. V. McCollum V. C. Myers, T. B. Osborne, A. N. Richards.

ATTENDANCE. J. G. Adami, S. Amberg, L. Baumann, H. C. Bradley, H. J. Corper, C. H. Fiske, W. E. Garrey, A. D. Hirschfelder, R. A. Hall, P. E. Howe, E. C. Kendall, B. Kramer, A. S. Loevenhart, G. Lusk, J. J. R. Macleod, V. H. Mottram, H. McGuigan, J. L. Morris, C. H. Neilson, E. W. Rockwood, P. A. Shaffer, T. Sollmann, C. Voegtlin, H. G. Wells, R. T. Woodyatt.

IV. AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS:

SIXTH ANNUAL MEETING

John Auer, Secretary.

The sixth annual meeting of the Pharmacol. Soc. was held in St. Louis, at the Washington Univ. Med. Sch., on December 27-30, 1914. There were five scientific sessions, three of them being joint meetings with the other members of the Federation. At the two independent sessions the following papers were read.

Scientific program. FIRST SESSION. MONDAY, DEC. 28, 2.00 p. m. S. Amberg and H. F. Helmholtz: The fatal dose of various substances on intravenous injection in the guinea-pig.-G. W. Crile: Experimental and clinical research into alkalescence, acidity and anesthesia.-P. J. Hanzlik: Effects of chelidonin on surviving organs.-T. Sollmann, W. L. Mendelhall and J. L. Stingle: The effect of temperature on the response of frogs to ouabain.-E. D. Brown: Artificial cerebral circulation after circulatory isolation of the mammalian brain. -Worth Hale: The uterine action of quinidin, cinchonin and cinchonidin. - C. D. Edmunds: Some vasomotor reactions in the liver.-T. S. Githens and S. J. Meltzer: Distribution of solutions in cardiectomized frogs with destroyed or inactive lymph hearts.-F. L. Gates and S. J. Meltzer: The influence of intra-intestinal administration of magnesium sulfate upon the production of hyalin casts in dogs.

SECOND SESSION. TUESDAY, DEC. 29, 9.00 a. m. W. deB. MасNider: A study of the relative importance of the vascular mechanism of the kidney and of the epithelial element of the kidney in determining the efficiency of various diuretics.-H. B. Myers: Crosstolerance of drugs.-H. B. Myers and G. B. Wallace: Vascular reactions in poisoning from diphtheria toxin.-A. D. Hirschfelder: The action of digitalis in experimental auricular fibrillation.-A. D. Hirschfelder: The effects of drugs upon the circulation in the Pia mater and the retinal vessels. - Clyde Brooks and J. D. Heard: The action of camphor on the circulation.-Don R. Joseph: The effect of carbon dioxid upon the convulsant action of acid fuchsin in frogs. Carl Voegtlin: The mechanism of the toxic action of heavy metals on the isolated heart.-C. W. Greene, L. R. Boutwell and J. O. Peeler: An analysis of the action of digitalin on the cardiac inhibitory centre and on the cardiac muscle.-W. H. Schultz: A comparative study of the influence of the solvent upon the toxicity of thymol.-W. H. Schultz: The reaction of hookworm larvae to certain chemicals. -A. E. Cohn: A further observation on the "Twave" when digitalis is given.

Executive proceedings. NEW MEMBERS: F. C. Becht, Univ. Chicago; W. H. Brown, F. L. Gates, Rockefeller Inst.

OFFICERS-ELECT: President-Torald Sollmann; SecretaryJohn Auer; Treasurer-Wm. deB. MacNider; Additional members of the Council-Worth Hale, D. E. Jackson. Membership Commit. -S. J. Meltzer (term expires 1917).

General comment. Among the topics discussed during the business meetings, was one especially which is of general interest. Several members expressed marked dissatisfaction with the present arrangement of holding the annual meetings during the Christmas holidays. They suggested that practically any other time would be better. Their arguments, briefly, were as follows: The Christmas sessions always break the holidays as a family festival for members who live at some distance from the place of annual meeting; it has not been uncommon for members to spend Christmas day on the train. Secondly, if the meetings were held in June or July,1 more time would be available for the completion of work started at the beginning of the academic year, so that it could be reported to the Society. In the third place, a meeting in June or July would mean equable climatic conditions during the sessions, and the attending members would be less likely to experience in a few days, more or less unprepared, samples of all the seasons as at present during the Christmas holidays.

There are, of course, objections to this suggested change. The gravest one, perhaps, is the fact that most of the Societies forming the Federation have clauses in their constitutions which fix the annual session in the last week of December and the first week of January. Now, without losing time in deploring the tendency to regulate and direct every manifestation of life in a Society by constitutional pro

1 The Easter holidays are not suitable as a meeting period because not all colleges and universities give a vacation, nor do the vacations coincide in time. visions, it may be remarked that even the necessity of a constitutional amendment should not permanently block an improvement. It must, however, be admitted that constitutions are not easily amended, that the channels to this fortress are tortuous and often mined, so that the unwary navigator is frequently blown up with astonishing ease by the orthodox defenders of the citadel.

This matter of altering the time of meeting has been mentioned here, not because of its novelty, for it has been discussed lightly on several occasions in the past, but in the hope that a majority of the Federation will take it under serious advisement.

Attendance. The attendance was excellent in general, but geographically it was ill-balanced, the eastern section of the country being represented by relatively few men. This absence, flatteringly enough for the Atlantic seaboard, caused a few subacid remarks.

Entertainment. TRIP AROUND ST. LOUIS. On Wednesday afternoon the Local Commit. arranged a series of enjoyable visits to the St. Louis Hospitals and laboratories, and also to the beautifully located and impressive buildings of Washington Univ.

Vote of thanks. At the last executive session of the Pharmacol. Soc. a motion was passed unanimously to thank the authorities of Washington Univ. for their hospitality and the Local Commit. for its broad and efficient efforts to render the stay of their guests in St. Louis as pleasant and profitable as possible.

V. AMERICAN SOCIETY FOR EXPERIMENTAL PATHOLOGY: SECOND ANNUAL MEETING

G. H. Whipple, Secretary

At the second annual meeting of the Pathol. Soc., in addition to participation in the three sessions of the Federation, papers were presented at an independent session.

Scientific program. MONDAY, DEC. 28, 2 p. m. E. C. Rosenow: Studies on streptococci.-B. S. Kline and S. J. Meltzer: The effect of previous intravenous injections of the pneumococcus upon experimental pneumonia by intra-bronchial insufflation of the same organism.-Ludvig Hektoen: Observations on the formation of anti-bodies. Leo Loeb: Autoplastic and homoloplastic transplantation of tissues.-H. T. Karsner: Further studies in nitrogen retention and renal function.-H. G. Wells: Metastatic calcification.